Combination therapy with intrapleural doxycycline and talc in reduced doses is effective in producing pleurodesis in rabbits


Dikensoy Ö., Zhu Z., Donnelly E., Stathopoulos G., Lane K., Light R.

CHEST, vol.128, no.5, pp.3735-3742, 2005 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 128 Issue: 5
  • Publication Date: 2005
  • Doi Number: 10.1378/chest.128.5.3735
  • Journal Name: CHEST
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED)
  • Page Numbers: pp.3735-3742
  • Keywords: combination, doxcycline, pleural effusion, talc, ultrasound, MALIGNANT PLEURAL EFFUSIONS, SPONTANEOUS PNEUMOTHORAX, TETRACYCLINE, BLEOMYCIN, CORTICOSTEROIDS, DIAGNOSIS, INSTILLATION, MINOCYCLINE, ULTRASOUND, MANAGEMENT
  • Acibadem Mehmet Ali Aydinlar University Affiliated: No

Abstract

Background: It has been suggested that talc and doxycycline might be acting through different pathways in creating pleurodesis. We hypothesized that combining doxycycline and talc in half the usual doses would be synergistic in inducing pleurodesis.