Combination therapy with intrapleural doxycycline and talc in reduced doses is effective in producing pleurodesis in rabbits

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Dikensoy Ö. , Zhu Z., Donnelly E., Stathopoulos G., Lane K., Light R.

CHEST, vol.128, no.5, pp.3735-3742, 2005 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 128 Issue: 5
  • Publication Date: 2005
  • Doi Number: 10.1378/chest.128.5.3735
  • Title of Journal : CHEST
  • Page Numbers: pp.3735-3742


Background: It has been suggested that talc and doxycycline might be acting through different pathways in creating pleurodesis. We hypothesized that combining doxycycline and talc in half the usual doses would be synergistic in inducing pleurodesis.