Anti-inflammatory effect of meloxicam on experimental vasospasm in the rat femoral artery
JOURNAL OF CLINICAL NEUROSCIENCE, cilt.15, sa.1, ss.55-59, 2008 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 15 Sayı: 1
- Basım Tarihi: 2008
- Doi Numarası: 10.1016/j.jocn.2006.10.010
- Dergi Adı: JOURNAL OF CLINICAL NEUROSCIENCE
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.55-59
- Anahtar Kelimeler: cerebral vasospasm, femoral artery, inflammation, meloxicam, subarachnoid haemorrhage, EXPERIMENTAL SUBARACHNOID HEMORRHAGE, DELAYED CEREBRAL VASOSPASM, BASILAR ARTERY, MODEL, INFLAMMATION, INHIBITION, IBUPROFEN, CYCLOOXYGENASE-2, PROSTACYCLIN, PREVENTION
- Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır
Özet
Cerebral vasospasm influences morbidity and mortality following subarachnoid haemorrhage (SAH). Inflammation is believed to play a role in post-haemorrhagic vasospasm. Meloxicam is a non-steroidal anti-inflammatory drug. We investigated the effect of meloxicam on a rat femoral artery vasospasm model using the radial wall thickness and cross-sectional lumen area as parameters under light, scanning and transmission electron microscopy examination. Rats were randomly separated into SAH, SAH + meloxicam and control groups. Rats in the SAH + meloxicam group were given meloxicam at 2 mg/kg daily for 7 days. Femoral arteries were examined by light microscopy and scanning and transmission electron microscopy, and for morphometric analysis. A statistically significant difference (p < 0.001) was detected between the SAH and SAH + meloxicam groups. Meloxicam treatment reduced ultrastructural and morphometric vasospastic changes. These findings support the hypothesis that inflammation may play a role in the pathophysiologyical pathways of post-haemorrhagic cerebral vasospasm. (C) 2006 Elsevier Ltd. All rights reserved.