Atıf İçin Kopyala
Çınar A. S., Rızvanoğlu S., Eryılmaz M., Demirci B., Önder A.
ANKARA UNIVERSITESI ECZACILIK FAKULTESI DERGISI, cilt.48, sa.2, ss.586-596, 2024 (Scopus)
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Yayın Türü:
Makale / Tam Makale
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Cilt numarası:
48
Sayı:
2
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Basım Tarihi:
2024
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Doi Numarası:
10.33483/jfpau.1416623
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Dergi Adı:
ANKARA UNIVERSITESI ECZACILIK FAKULTESI DERGISI
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Derginin Tarandığı İndeksler:
Scopus, Central & Eastern European Academic Source (CEEAS), EMBASE, TR DİZİN (ULAKBİM)
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Sayfa Sayıları:
ss.586-596
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Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli:
Hayır
Özet
Objective: The study aimed to determine the chemical composition and antibacterial, antibiofilm, and anti-quorum sensing activities of the essential oil of Salvia absconditiflora Greuter & Burdet (an endemic species) growing wildly in Türkiye.
Material and Method: The essential oil from the aerial parts of the plant was obtained by hydro-distillation (0.4%) and analyzed by GC-FID and GC-MS. In addition, the broth microdilution method was used to determine antibacterial activity. The crystal violet assay was performed for antibiofilm activity, and the reporter bacteria Chromobacterium violaceum ATCC 12472 was used in the anti-quorum sensing activity test.
Result and Discussion: The major components of the essential oil were identified as 1,8-cineole (32.2%), camphor (13.6%), α-pinene (7.6%), camphene (5.5%), and viridiflorol (5.1%). The essential oil showed the best antibacterial activity against Gram-positive test bacteria, with a minimum inhibitory concentration (MIC) of 0.0078 (v/v) against Staphylococcus aureus strains. The percentage biofilm inhibition value of the essential oil was determined as 84.4%. The inhibition of violacein production by the essential oil in Chromobacterium violaceum ATCC 12472 indicated the possibility of anti-quorum sensing activity. The results of this study show that the essential oil of S. absconditiflora could be a promising alternative in fighting bacterial infections.