Evaluation of ototoxicity of intratympanic administration of Methotrexate in rats


EREN S. B. , DOĞAN R., YENİGÜN A., Veyseller B., Tugrul S., ÖZTURAN O., et al.

INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY, cilt.100, ss.132-136, 2017 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 100
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1016/j.ijporl.2017.06.035
  • Dergi Adı: INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY
  • Sayfa Sayısı: ss.132-136

Özet

Objective: Methotrexate is a dihydrofolate reductase enzyme inhibitor with very high selectivity, and it is an antiproliferative folic acid antagonist used for the treatment of autoimmune diseases. In this study, our objective was to evaluate the effect of intratympanic Methotrexate application in the inner ear.