Evaluation of ototoxicity of intratympanic administration of Methotrexate in rats


EREN S. B. , DOĞAN R., YENİGÜN A., Veyseller B., Tugrul S., ÖZTURAN O., ...More

INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY, vol.100, pp.132-136, 2017 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 100
  • Publication Date: 2017
  • Doi Number: 10.1016/j.ijporl.2017.06.035
  • Title of Journal : INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY
  • Page Numbers: pp.132-136

Abstract

Objective: Methotrexate is a dihydrofolate reductase enzyme inhibitor with very high selectivity, and it is an antiproliferative folic acid antagonist used for the treatment of autoimmune diseases. In this study, our objective was to evaluate the effect of intratympanic Methotrexate application in the inner ear.