Glycerol and galactose substituted zinc phthalocyanines. Synthesis and photodynamic activity

Zorlu Y., Ermeydan M. A., DUMOULIN F., Ahsen V., Savoie H., Boyle R. W.

PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES, cilt.8, sa.3, ss.312-318, 2009 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 8 Sayı: 3
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1039/b817348f
  • Dergi Adı: PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.312-318
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

Three novel water soluble, non-ionic, zinc phthalocyanines (Pcs) have been synthesized and their spectroscopic and photodynamic properties investigated in aqueous media. One of the three compounds was shown to be significantly less aggregated, when compared to the other two compounds, and this effect was found to be related to both the nature of the substituent, and also the position at which it is attached to the macrocycle. Photodynamic activity and cellular uptake by human adenocarcinoma cells (HT-29) was shown to be linked to the aggregation state of the Pcs in water.