Akademik Veri Yönetim Sistemi
SPINE JOURNAL, cilt.9, sa.12, ss.981-986, 2009 (SCI-Expanded)
BACKGROUND CONTEXT: Neuromuscular disorders (NMD) are characterized by loss of lung Volume and respiratory muscle weakness, but the effects of scoliosis on lung function are unclear. PURPOSE: To compare pulmonary function and respirator), muscle strength in patients with NMD with and without scoliosis as Well its in healthy controls. STUDY DESIGN/SETTING: Prospective comparison of pulmonary function testing and respiratory muscle strength were made at the pediatric pulmonology and cardiopulmonary rehabilitation units of a university hospital. PATIENT SAMPLE: Twenty-two patients with NMD and scoliosis, 17 patients with NMD without scoliosis, and 24 age- and sex-matched healthy controls. Outcome measures were compared in patients with NMD with and without scoliosis and healthy subjects using Student t test, Mann-Whitney U test, chi-square test, one-way analysis of variance (ANOVA), Kruskal-Wallis one-way ANOVA, Pearson correlation coefficients, and Spearman rank correlation, as appropriate. OUTCOME MEASURES: 1) Pulmonary function: forced vital capacity (FVC), forced expiratory volume in I second (FEV1), peak expiratory flow rate (PEF), forced expiratory flow between 25% and 75% of FVC (FEF25-75%), and maximum expiratory flows at 75%, 50%, and 25% of FVC (MEF75, MEF50, and MEF25, respectively); 2) oxygen saturation: pulse oxymeter readings and 3) respiratory muscle strength: maximal inspiratory mouth pressure (MIP) and maximal expiratory mouth pressure (MEP). METHODS: Pulmonary function, oxygen saturation, MIP, and MEP were measured and compared in patients with NMD, patients with and without scoliosis, and in healthy Subjects. RESULTS: The patients with NMD, both with and without scoliosis, had significantly lower PEF, MIP, MEP, % predicted MIP (%MIP), and % predicted MEP (%MEP) than those of healthy Subjects (p<.05). The patients with NMD and scoliosis had significantly, lower values than those with NMD without scoliosis and controls (p<.05) for FVC, FEV1, and FEF25-75% CONCLUSION: Both inspiratory and expiratory muscle strength were diminished in patients with NMD compared with healthy controls. Significant differences were also noted in pulmonary function in patients with NMD with or without scoliosis. This suggests that NMD may impact respiratory function independently of the effects of scoliosis. Clinicians treating patients with NMD should be aware of the possibility of compromised respiratory function in these patients to address possible complications. (C) 2009 Elsevier Inc. All rights reserved.