Effects of selective COX-2 inhibitors on the gastric permeability of sucrose: a controlled study with placebo and ibuprofen
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, cilt.15, sa.4, ss.403-406, 2003 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 15 Sayı: 4
- Basım Tarihi: 2003
- Doi Numarası: 10.1097/00042737-200304000-00011
- Dergi Adı: EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.403-406
- Anahtar Kelimeler: COX-2 inhibitors, gastric damage, sucrose permeability, RANDOMIZED CONTROLLED TRIAL, RHEUMATOID-ARTHRITIS, DOUBLE-BLIND, CYCLOOXYGENASE-2 INHIBITORS, GASTROINTESTINAL TOXICITY, OSTEOARTHRITIS, ROFECOXIB, CELECOXIB, EFFICACY, TOLERABILITY
- Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır
Özet
Objective Acute and chronic use of non-steroidal anti-inflammatory drugs can increase gastrointestinal permeability. Celecoxib, which selectively inhibits the enzyme cyclooxygenase-2, is a novel anti-inflammatory drug with minimal gastrointestinal toxic effects while retaining anti-inflammatory efficacy. Our aim was to assess the potential effects of celecoxib on gastric permeability in comparison with placebo and ibuprofen.