Effects of selective COX-2 inhibitors on the gastric permeability of sucrose: a controlled study with placebo and ibuprofen
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, vol.15, no.4, pp.403-406, 2003 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 15 Issue: 4
- Publication Date: 2003
- Doi Number: 10.1097/00042737-200304000-00011
- Journal Name: EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.403-406
- Keywords: COX-2 inhibitors, gastric damage, sucrose permeability, RANDOMIZED CONTROLLED TRIAL, RHEUMATOID-ARTHRITIS, DOUBLE-BLIND, CYCLOOXYGENASE-2 INHIBITORS, GASTROINTESTINAL TOXICITY, OSTEOARTHRITIS, ROFECOXIB, CELECOXIB, EFFICACY, TOLERABILITY
- Acibadem Mehmet Ali Aydinlar University Affiliated: No
Abstract
Objective Acute and chronic use of non-steroidal anti-inflammatory drugs can increase gastrointestinal permeability. Celecoxib, which selectively inhibits the enzyme cyclooxygenase-2, is a novel anti-inflammatory drug with minimal gastrointestinal toxic effects while retaining anti-inflammatory efficacy. Our aim was to assess the potential effects of celecoxib on gastric permeability in comparison with placebo and ibuprofen.