Effects of selective COX-2 inhibitors on the gastric permeability of sucrose: a controlled study with placebo and ibuprofen

Ekenel M., Avsar E., Imeryuz N., Yuksel M., Haklar G., Kocakaya O., ...More

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, vol.15, no.4, pp.403-406, 2003 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 15 Issue: 4
  • Publication Date: 2003
  • Doi Number: 10.1097/00042737-200304000-00011
  • Journal Name: EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.403-406
  • Keywords: COX-2 inhibitors, gastric damage, sucrose permeability, RANDOMIZED CONTROLLED TRIAL, RHEUMATOID-ARTHRITIS, DOUBLE-BLIND, CYCLOOXYGENASE-2 INHIBITORS, GASTROINTESTINAL TOXICITY, OSTEOARTHRITIS, ROFECOXIB, CELECOXIB, EFFICACY, TOLERABILITY
  • Acibadem Mehmet Ali Aydinlar University Affiliated: No

Abstract

Objective Acute and chronic use of non-steroidal anti-inflammatory drugs can increase gastrointestinal permeability. Celecoxib, which selectively inhibits the enzyme cyclooxygenase-2, is a novel anti-inflammatory drug with minimal gastrointestinal toxic effects while retaining anti-inflammatory efficacy. Our aim was to assess the potential effects of celecoxib on gastric permeability in comparison with placebo and ibuprofen.