Effects of selective COX-2 inhibitors on the gastric permeability of sucrose: a controlled study with placebo and ibuprofen

Ekenel M., Avsar E., Imeryuz N., Yuksel M., Haklar G., Kocakaya O., ...Daha Fazla

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, cilt.15, sa.4, ss.403-406, 2003 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 15 Sayı: 4
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1097/00042737-200304000-00011
  • Dergi Adı: EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.403-406
  • Anahtar Kelimeler: COX-2 inhibitors, gastric damage, sucrose permeability, RANDOMIZED CONTROLLED TRIAL, RHEUMATOID-ARTHRITIS, DOUBLE-BLIND, CYCLOOXYGENASE-2 INHIBITORS, GASTROINTESTINAL TOXICITY, OSTEOARTHRITIS, ROFECOXIB, CELECOXIB, EFFICACY, TOLERABILITY
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

Objective Acute and chronic use of non-steroidal anti-inflammatory drugs can increase gastrointestinal permeability. Celecoxib, which selectively inhibits the enzyme cyclooxygenase-2, is a novel anti-inflammatory drug with minimal gastrointestinal toxic effects while retaining anti-inflammatory efficacy. Our aim was to assess the potential effects of celecoxib on gastric permeability in comparison with placebo and ibuprofen.