The SOCS-1 gene methylation in chronic myeloid leukemia patients


Hatirnaz M. , Ure U., Ar C., Akyerli C. , Soysal T., Ferhanoglu B., ...More

American Journal of Hematology, vol.82, no.8, pp.729-730, 2007 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 82 Issue: 8
  • Publication Date: 2007
  • Doi Number: 10.1002/ajh.20886
  • Title of Journal : American Journal of Hematology
  • Page Numbers: pp.729-730

Abstract

SOCS-1, an important protein in the JAK/STAT pathway, has a role in the down steam of BCR-ABL protein kinase. We investigated 56 CML patients and 16 controls for the methylation status of SOCS-1 gene promoter and Exon 2 regions. Exon 2 was found to be methylated in 58.9% of the patients and 93.8% of the controls [P = 0.020, OR = 0.121(0.015-0.957)%95Cl]. The promoter region was found unmethylated in all patient samples and controls. Although previous studies revealed a relation between SOCS-1 gene Exon-2 hypermethylation and CML development or progression, the results of this study showed no such correlation. On the contrary, our results might be indicating hypomethylation in CML patients, this hypothesis need to be studied in larger study population.