Akademik Veri Yönetim Sistemi
Uluslararası Biyokimya Kongresi, Antalya, Türkiye, 29 Ekim - 01 Kasım 2023, ss.88-89
RETROSPECTIVE
INVESTIGATION OF THYROID HEALTH IN BREAST CANCER PATIENTS
Bengisu Dönmez1,Muhittin Serdar1,2,
Aysel Özpınar 1,2
1 Biochemistry
ve Molecular Biology Dept., Institute of Health Sciences, Acibadem Mehmet Ali
Aydınlar University, İstanbul/ Türkiye
2 Acıbadem Mehmet
Ali Aydınlar University, School of Medicine, Medical Biochemistry Dept.,
İstanbul/Türkiye
Objective: Breast cancer is one of the most
common types of cancer in women worldwide. Thyroid hormones play an important
role in regulating metabolism and cell growth, including in breast tissue.
Although a potential link between thyroid health and breast cancer risk has
been suggested in the literature, highly conflicting results have been
obtained, and the relationship between them remains unclear.
Aim: The aim of this study is to examine thyroid functions
and autoimmunity in breast cancer patients and to define the possible
relationship between breast cancer and thyroid health.
Material and Method: The data of 815 patients included in the study,
including 40 patients diagnosed with breast cancer, 79 patients with benign
breast disease, and 696 patients in the control group, who applied to the
hospitals and medical centers within the Acıbadem Healthcare Group between 2002
and 2022 and had thyroid function tests, were included in this study. SPSS 26
program was used for comparing the thyroid hormones and autoantibody levels of
breast cancer patients with those with benign breast disease and the control
group, statistically.
Results: As a result, anti-thyroglobulin antibody
(anti-TG) levels were found to be higher in breast cancer patients compared to
other groups, and the risk rate of breast cancer in anti-TG positive women was
3.57 times higher than in anti-TG negative patients. In addition, the anti-TG
antibody diagnostic performance was better than an anti-TPO antibody. As a
result of this study, it was determined
that anti-TG antibody was positivity associated with a high risk of breast
cancer.
Conclusion: This finding is important in terms of
demonstrating the necessity of routine screening of thyroid autoantibody
levels. However, further research is needed to elucidate the mechanisms underlying
this association and to explore the potential of the anti-TG antibody as a biomarker
for breast cancer risk.
Keywords: Benign Breast Diseases, Breast Cancer,
Thyroid Antibodies, Thyroid Hormones