Akademik Veri Yönetim Sistemi
TuPA International Proteomics Congress 7 Turkish National Proteomics Congress, İstanbul, Türkiye, 18 - 19 Eylül 2025, ss.39, (Özet Bildiri)
Aim: The effects of ω9 fatty acids (FAs) on human health have been less studied than those of ω3 and ω6 FAs. Until recently, colostrum ω9 FA studies were limited to Asian countries, which consistently demonstrated that ω9 FAs are most abundant in colostrum and decrease as lactation progresses. Recent European studies confirmed that ω9 erucic, gondoic, and nervonic acids are most abundant in colostrum, decreasing later, and are even higher in the colostrum of mothers with premature deliveries. ω9 FAs stimulate the brown adipose tissues, rapidly generating heat; thus, a relationship with birth weight was presumed. Furthermore, the colostrum and transitional milk production interval aligns with the period when neurocognitive development is vulnerable to a deficiency of thyroid hormones (THs), which regulate fetal adipogenesis. Based on these backgrounds, we analyzed associations between colostrum FAs, birth weight, and THs. Methods: 22 FAs in the colostrum of 78 healthy mothers were measured with LC-MS/MS. FT3, FT4, and TSH levels were analyzed in the mothers' serum, and newborns' TSH in heel-pricked specimens. Correlations were defined in subsets, separated according to birth weight, THs, and mothers' body mass index, with Phyton Software. Results: In the entire cohort, five of 22 FAs correlated with birth weight, all positively, including ω9 gondoic, erucic, and nervonic acids, and also saturated behenic and lignoceric acids, produced by the same elongases. These correlations sustained for gondoic, nervonic, behenic, and lignoceric acids among mothers with low FT4, and for erucic acid among mothers with high TSH. Conclusions: The breast epithelial cells are prepared prenatally to adjust colostrum quality by shared mechanisms with fetal fat accrual. Thus, ω9 monounsaturated and saturated FAs over 18 carbon length may be released more into the colostrum to support thermoregulation against the harm of TH deficiencies. Keywords: 9 Fatty Acids, Hypothyroid Stages, Newborn Health