The correlation between prostate-specific antigen and age - Analysis of prostate-specific antigen values from 4,846 Turkish men with symptomatic benign prostatic hyperplasia

Uygur M., Erol D., Cetinkaya M., Gungen Y., Laleli Y., Altug U.

EUROPEAN UROLOGY, vol.32, no.4, pp.416-419, 1997 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 32 Issue: 4
  • Publication Date: 1997
  • Journal Name: EUROPEAN UROLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.416-419
  • Acibadem Mehmet Ali Aydinlar University Affiliated: Yes

Abstract

Objective: To analyze serum prostate-specific antigen (PSA) levels of men proven to have benign prostatic hyperplasia (BPH) and to document any correlation between PSA, age and resected or enucleated prostate tissue. Patients and Methods: Serum PSA values, age and weight of specimens of 4,846 men who underwent prostatectomy in the Ankara region between January 1, 1991, and December 24, 1995, were reviewed retrospectively. Results: Serum PSA values correlated directly with age (Pearson's r = 0.45, p < 0.00001). The mean PSA values of men in each decade of age differed significantly (p < 0.0001) from all other decades. However, the correlation between the weight of the prostatectomy specimen and age or PSA did not reach statistical significance. Conclusion: The effect of age on PSA is evident in men with symptoms of BPH. The existence of symptomatic BPH should also be considered together with age when interpreting PSA levels.