Meningiomas Display a Specific Immunoexpression Pattern in a Rostrocaudal Gradient: An Analysis of 366 Patients

Ulgen E., Bektasoglu P. K., Sav M. A., CAN Ö., ERŞEN DANYELİ A., Hizal D. B., ...More

WORLD NEUROSURGERY, vol.123, 2019 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 123
  • Publication Date: 2019
  • Doi Number: 10.1016/j.wneu.2018.11.201
  • Journal Name: WORLD NEUROSURGERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: Immunohistochemistry, Meningioma, Survival, TUMOR-LOCALIZATION, PROGNOSTIC VALUE, MUTATIONS, DIAGNOSIS, CLASSIFICATION, PROLIFERATION, PROGRESSION, EXPRESSION, SYSTEM, TRAF7
  • Acibadem Mehmet Ali Aydinlar University Affiliated: Yes

Abstract

BACKGROUND: Meningiomas are heterogeneous, with differences in anatomical, histopathological, and clinical characteristics. Such spatial variability in meningioma biology is thought to result from differences in the expression of critical developmental regulators. We hypothesized that the variability in meningioma biology would follow gradients such as in embryology and tested a cohort of 366 meningiomas for histopathological and immunohistochemical gradients.