Meningiomas Display a Specific Immunoexpression Pattern in a Rostrocaudal Gradient: An Analysis of 366 Patients.


Ülgen E., Bektaşoğlu P., Sav M., Can Ö. , Danyeli A. , Hızal D. , ...More

World neurosurgery, vol.123, 2019 (Journal Indexed in SCI Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 123
  • Publication Date: 2019
  • Doi Number: 10.1016/j.wneu.2018.11.201
  • Title of Journal : World neurosurgery

Abstract

BACKGROUND: Meningiomas are heterogeneous, with differences in anatomical, histopathological, and clinical characteristics. Such spatial variability in meningioma biology is thought to result from differences in the expression of critical developmental regulators. We hypothesized that the variability in meningioma biology would follow gradients such as in embryology and tested a cohort of 366 meningiomas for histopathological and immunohistochemical gradients.