Meningiomas Display a Specific Immunoexpression Pattern in a Rostrocaudal Gradient: An Analysis of 366 Patients

Ulgen E., Bektasoglu P. K., Sav M. A., CAN Ö., ERŞEN DANYELİ A., Hizal D. B., ...Daha Fazla

WORLD NEUROSURGERY, cilt.123, 2019 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 123
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1016/j.wneu.2018.11.201
  • Dergi Adı: WORLD NEUROSURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: Immunohistochemistry, Meningioma, Survival, TUMOR-LOCALIZATION, PROGNOSTIC VALUE, MUTATIONS, DIAGNOSIS, CLASSIFICATION, PROLIFERATION, PROGRESSION, EXPRESSION, SYSTEM, TRAF7
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Evet

Özet

BACKGROUND: Meningiomas are heterogeneous, with differences in anatomical, histopathological, and clinical characteristics. Such spatial variability in meningioma biology is thought to result from differences in the expression of critical developmental regulators. We hypothesized that the variability in meningioma biology would follow gradients such as in embryology and tested a cohort of 366 meningiomas for histopathological and immunohistochemical gradients.