Global fibrinolytic capacity in patients with subclinical hypothyroidism

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Guldiken S., Demir M., Turgut B., Altun B., Arikan E., Kara M.

ENDOCRINE JOURNAL, vol.52, no.3, pp.363-367, 2005 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 52 Issue: 3
  • Publication Date: 2005
  • Doi Number: 10.1507/endocrj.52.363
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.363-367
  • Keywords: subdinical hypothyroidism, global fibrinolytic capacity, hypothyroidism, fibrinolytic system, THYROID-DISEASE, RISK-FACTOR, CARDIOVASCULAR-DISEASE, MYOCARDIAL-INFARCTION, HEMOSTATIC SYSTEM, PLASMA, STATE, ATHEROSCLEROSIS, EPIDEMIOLOGY, MARKERS
  • Acibadem Mehmet Ali Aydinlar University Affiliated: Yes


Subclinical hypothyroidism (SH) represents the earliest stages of hypothyroidism but the benefits of detecting and treating SH are not well known. The aim of this Study was to evaluate the alterations in global fibrinolytic capacity (GFC), which indicates the overall fibrinolytic activity, in patients with SH. The study group comprised of 15 patients with SH and 15 healthy controls. The GFC was significantly lower in patients with SH than in control group (p < 0.002). This result suggests a relative hypercoagulable state in SH.