Does pregnancy-associated plasma protein A have a role in allergic rhinitis?

Guclu E., Coskun A., Tokmak A., Duran S., Ozturk O., Akkan N., ...More

AMERICAN JOURNAL OF RHINOLOGY, vol.22, no.3, pp.219-222, 2008 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 22 Issue: 3
  • Publication Date: 2008
  • Doi Number: 10.2500/ajr.2008.22.3179
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.219-222
  • Keywords: allergic rhinitis, hypervascularity, IGF, IGFBP-4, inflammation, matrix metalloproteinase, nasal mucosa, PAPP-A, pregnancy, tissue remodeling, SMOOTH-MUSCLE CELLS, GROWTH-FACTORS, INCREASED EXPRESSION, NASAL-MUCOSA, ASTHMA, MATRIX-METALLOPROTEINASE-9, BINDING, FIBROBLASTS, INHIBITOR, INCREASES
  • Acibadem Mehmet Ali Aydinlar University Affiliated: Yes


Background: Pregnancy-associated plasma protein A (PAPP-A), also known as insulin-like growth factor binding protein 4 protease, is postulated to be a new inflammatory marker in various clinical situations such as cardiovascular events, dialysis, renal transplantation, and asthma. PAPP-A also is produced in high concentrations by trophoblasts during pregnancy.