Simvastatin therapy in lymphocyte cross-match-positive kidney transplantation candidates


Yakupoglu Ü. , Kocak H., Karatas G., Yakupoglu Y., Dinckan A., Kececioglu N., ...More

TRANSPLANTATION PROCEEDINGS, vol.37, no.7, pp.2933-2935, 2005 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 37 Issue: 7
  • Publication Date: 2005
  • Doi Number: 10.1016/j.transproceed.2005.07.034
  • Title of Journal : TRANSPLANTATION PROCEEDINGS
  • Page Numbers: pp.2933-2935

Abstract

Objectives. Recent identification of several mechanisms by which statins decrease recruitment of monocytes and T cells into the arterial wall and inhibit both T-cell and B-cell activation and proliferation in vitro prompted us to study the immunomodulatory effects of statins. In this study, we examined the effect of simvastatin therapy on lymphocyte cross-match positivity in kidney transplantation candidates.