Simvastatin therapy in lymphocyte cross-match-positive kidney transplantation candidates

Yakupoglu Ü. , Kocak H., Karatas G., Yakupoglu Y., Dinckan A., Kececioglu N., et al.

TRANSPLANTATION PROCEEDINGS, cilt.37, ss.2933-2935, 2005 (SCI İndekslerine Giren Dergi) identifier identifier identifier


Objectives. Recent identification of several mechanisms by which statins decrease recruitment of monocytes and T cells into the arterial wall and inhibit both T-cell and B-cell activation and proliferation in vitro prompted us to study the immunomodulatory effects of statins. In this study, we examined the effect of simvastatin therapy on lymphocyte cross-match positivity in kidney transplantation candidates.