Localisation analysis of nerves in the mouse pancreas reveals the sites of highest nerve density and nociceptive innervation

Saricaoglu O. C., Teller S., Wang X., Wang S., Stupakov P., Heinrich T., ...More

NEUROGASTROENTEROLOGY AND MOTILITY, vol.32, no.11, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 32 Issue: 11
  • Publication Date: 2020
  • Doi Number: 10.1111/nmo.13880
  • Journal Name: NEUROGASTROENTEROLOGY AND MOTILITY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, MEDLINE
  • Keywords: BDNF, mouse, nerve trunks, nitrergic, pain, pancreas, GENE-RELATED PEPTIDE, CHRONIC INFLAMMATION, NEURAL PLASTICITY, PAIN, EXPRESSION, NEURONS, BDNF, CANCER, NEUROPATHY, INVASION
  • Acibadem Mehmet Ali Aydinlar University Affiliated: Yes

Abstract

Background Neuropathy and neuro-inflammation drive the severe pain and disease progression in human chronic pancreatitis and pancreatic cancer. Mice, especially genetically induced-mouse models, have been increasingly utilized in mechanistic research on pancreatic neuropathy, but the normal "peripheral neurobiology" of the mouse pancreas has not yet been critically compared to human pancreas.