Localisation analysis of nerves in the mouse pancreas reveals the sites of highest nerve density and nociceptive innervation


Saricaoglu O. C. , Teller S., Wang X., Wang S., Stupakov P., Heinrich T., ...More

NEUROGASTROENTEROLOGY AND MOTILITY, 2020 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume:
  • Publication Date: 2020
  • Doi Number: 10.1111/nmo.13880
  • Journal Name: NEUROGASTROENTEROLOGY AND MOTILITY
  • Journal Indexes: Science Citation Index Expanded
  • Keywords: BDNF, mouse, nerve trunks, nitrergic, pain, pancreas, GENE-RELATED PEPTIDE, CHRONIC INFLAMMATION, NEURAL PLASTICITY, PAIN, EXPRESSION, NEURONS, BDNF, CANCER, NEUROPATHY, INVASION

Abstract

Background Neuropathy and neuro-inflammation drive the severe pain and disease progression in human chronic pancreatitis and pancreatic cancer. Mice, especially genetically induced-mouse models, have been increasingly utilized in mechanistic research on pancreatic neuropathy, but the normal "peripheral neurobiology" of the mouse pancreas has not yet been critically compared to human pancreas.