Localisation analysis of nerves in the mouse pancreas reveals the sites of highest nerve density and nociceptive innervation

Saricaoglu, Oemer; Teller, Steffen; Wang, Xiaobo; Wang, Shenghan; Stupakov, Pavel; Heinrich, Tobias; Istvanffy, Rouzanna; Friess, Helmut; Ceyhan, GÜRALP; Demir, Ihsan

doi:10.1111/nmo.13880

Localisation analysis of nerves in the mouse pancreas reveals the sites of highest nerve density and nociceptive innervation

Saricaoglu O. C., Teller S., Wang X., Wang S., Stupakov P., Heinrich T., ...Daha Fazla

NEUROGASTROENTEROLOGY AND MOTILITY, cilt.32, sa.11, 2020 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 32 Sayı: 11
Basım Tarihi: 2020
Doi Numarası: 10.1111/nmo.13880
Dergi Adı: NEUROGASTROENTEROLOGY AND MOTILITY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, MEDLINE
Anahtar Kelimeler: BDNF, mouse, nerve trunks, nitrergic, pain, pancreas, GENE-RELATED PEPTIDE, CHRONIC INFLAMMATION, NEURAL PLASTICITY, PAIN, EXPRESSION, NEURONS, BDNF, CANCER, NEUROPATHY, INVASION
Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Evet

Özet

Background Neuropathy and neuro-inflammation drive the severe pain and disease progression in human chronic pancreatitis and pancreatic cancer. Mice, especially genetically induced-mouse models, have been increasingly utilized in mechanistic research on pancreatic neuropathy, but the normal "peripheral neurobiology" of the mouse pancreas has not yet been critically compared to human pancreas.