Localisation analysis of nerves in the mouse pancreas reveals the sites of highest nerve density and nociceptive innervation
NEUROGASTROENTEROLOGY AND MOTILITY, vol.32, no.11, 2020 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 32 Issue: 11
- Publication Date: 2020
- Doi Number: 10.1111/nmo.13880
- Journal Name: NEUROGASTROENTEROLOGY AND MOTILITY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, MEDLINE
- Keywords: BDNF, mouse, nerve trunks, nitrergic, pain, pancreas, GENE-RELATED PEPTIDE, CHRONIC INFLAMMATION, NEURAL PLASTICITY, PAIN, EXPRESSION, NEURONS, BDNF, CANCER, NEUROPATHY, INVASION
- Acibadem Mehmet Ali Aydinlar University Affiliated: Yes
Abstract
Background Neuropathy and neuro-inflammation drive the severe pain and disease progression in human chronic pancreatitis and pancreatic cancer. Mice, especially genetically induced-mouse models, have been increasingly utilized in mechanistic research on pancreatic neuropathy, but the normal "peripheral neurobiology" of the mouse pancreas has not yet been critically compared to human pancreas.