Pediatric Osteoporosis and Vitamin D

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Semiz S.

Bone health and Pediatric Osteoporosis, Gülay Karagüzel,Yusuf Henan Haspolat, Editör, Orient Yayınları, İstanbul, ss.152-163, 2024

  • Yayın Türü: Kitapta Bölüm / Diğer
  • Basım Tarihi: 2024
  • Yayınevi: Orient Yayınları
  • Basıldığı Şehir: İstanbul
  • Sayfa Sayıları: ss.152-163
  • Editörler: Gülay Karagüzel,Yusuf Henan Haspolat, Editör
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Evet

Özet

Vitamin D, which acts similarly to a hormone, is essential for preserving skeletal health and regulating mineral metabolism. It directly affects osteoblasts and osteoclasts and interacts with non-skeletal tissues to balance bone turnover and growth. Vitamin D influences the activities of osteoblasts, osteoclasts, and osteocytes, indicating its impact on bone formation, resorption, and quality. Nutritional vitamin D plays a crucial role in regulating osteoblasts and has diverse effects that aid in the bone remodeling process during osteoporosis treatment. At normal physiological levels, active vitamin D maintains a normal rate of bone resorption and formation through the RANKL/osteoprotegerin (OPG) signaling pathway. However, at pharmacological concentrations active vitamin D inhibits bone resorption to a greater extent than bone formation, which affects both bone quality and quantity. Vitamin D deficiency is associated with low bone quality and quantity, while pharmacological concentrations of active vitamin D can potentially harm osteoblasts (4)