Overexpression of miR-145-5p Inhibits Proliferation of Prostate Cancer Cells and Reduces SOX2 Expression
CANCER INVESTIGATION, cilt.33, sa.6, ss.251-258, 2015 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 33 Sayı: 6
- Basım Tarihi: 2015
- Doi Numarası: 10.3109/07357907.2015.1025407
- Dergi Adı: CANCER INVESTIGATION
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.251-258
- Anahtar Kelimeler: hsa-miR-145-5p, SOX2, Prostate cancer, Stem cell marker, Cancer stem cell, MICRORNA EXPRESSION, TARGETS, GENES, DATABASE
- Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır
Özet
We aimed to perform functional analysis of miR-145-5p in prostate cancer (PCa) cells and to identify targets of miR-145-5p for understanding its role in PCa pathogenesis. PC3, DU145, LNCaP PCa, and PNT1a nontumorigenic prostate cell lines were utilized for functional analysis of miR-145-5p. Its overexpression caused inhibition of proliferation through apoptosis and reduced migration in PCa cells. SOX2 expression was significantly decreased in both mRNA and protein level in miR-145-5p-overexpressed PCa cells. We proposed that miR-145-5p, being an important regulator of SOX2, carries a crucial role in PCa tumorigenesis.