Effect of nitrogen mustard, a vesicant agent, on lymphocyte energy metabolism

Kenar L., Boyunaga H., Serdar M. A., Karayilanoglu T., Erbil M. K.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE, vol.44, no.10, pp.1253-1257, 2006 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 44 Issue: 10
  • Publication Date: 2006
  • Doi Number: 10.1515/cclm.2006.220
  • Journal Name: CLINICAL CHEMISTRY AND LABORATORY MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1253-1257
  • Keywords: energy metabolism, glycogen degradation, glycolysis, mechlorethamine, mustard, BUTYL 2-CHLOROETHYL SULFIDE, SULFUR MUSTARD, SUBCUTANEOUS INJECTION, WARFARE AGENT, GENERATION, MECHANISM, APOPTOSIS, MIRACIDIA, GLUCOSE
  • Acibadem Mehmet Ali Aydinlar University Affiliated: No

Abstract

Background: The vesicant agents sulfur and nitrogen mustards, which contain chloroethyl groups, are potent inhibitors of DNA synthesis and cell growth, likely changing the utilization of anaerobic glycolysis for energy generation.