Akademik Veri Yönetim Sistemi
TURKISH JOURNAL OF PATHOLOGY, cilt.21, sa.1-2, ss.24-26, 2005 (ESCI)
Glandular differentiation is the rarest form of heterologous differentiation in peripheral nerve sheath tumors, Glandular neurofibroma is a lesion characterized by profliferation of spindle cells admixed with mucous secreting glands. In the literature benign glandular elements exitence were reported in Schwannoma and malignant peripheral nerve sheath tumor whereas glandular neurofibromas were rarely reported. Presented case was a 56 year old woman with a 10 year history of a nodule on the left lower leg and local excision of this nodule was performed/ On macroscopic examination the cut surface of the nodule revealed multiple cystic spaces. some of which reaching 1 mm in size. On microscopic examination the lesion was composed of irregular bundles of spindle cells that most of which parallel to each other. The lesion was moderaterly cellular and has an infiltrative border with the surrounding adipose tissue. The glands were lined by cuboidal to columnar cells. Amorphous eosinophilic material was observed in some of the glandular lumers. The spindle cells were positive with S-100 the glandular epithelium were positive with cylokeratin. The epithelial cells contained PAS and d-PAS positive neutral mucin while the glandular epithelium and luninal secret had mucicarmen positive acidin mucin, Mast cells were domonstrated with totuidine blue and with all this feature the case was found to be suited with a glandular neurofibroma.