Independent association between serum sclerostin levels and carotid artery atherosclerosis in prevalent haemodialysis patients


Kirkpantur A., Balci M., Turkvatan A., Afsar B.

CLINICAL KIDNEY JOURNAL, vol.8, no.6, pp.737-743, 2015 (Journal Indexed in ESCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 8 Issue: 6
  • Publication Date: 2015
  • Doi Number: 10.1093/ckj/sfv077
  • Title of Journal : CLINICAL KIDNEY JOURNAL
  • Page Numbers: pp.737-743

Abstract

Background: Sclerostin is a soluble inhibitor of the Wntsignalling pathway and has been shown to be associated with decreased bone turnover and vascular and/or valvular calcification in patients with chronic kidney disease. Common carotid artery intima-media thickness (CIMT) assessment and common carotid artery (CCA) plaque identification with ultrasound imaging are well-recognized tools for the identification and monitoring of atherosclerosis. The aim of the present study was to investigate whether the circulating levels of sclerostin might be associated with carotid artery atherosclerosis in prevalent haemodialysis patients.