The effect of 5-fluorouracil and cisplatin on CA 125, CA 15-3 and CA 19-9 laboratory results


COSKUN A. , Yavuz Ö., Şahin I. E. , Güler S.

Turkiye Klinikleri Journal of Medical Sciences, vol.26, no.2, pp.117-120, 2006 (Journal Indexed in SCI Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 26 Issue: 2
  • Publication Date: 2006
  • Title of Journal : Turkiye Klinikleri Journal of Medical Sciences
  • Page Numbers: pp.117-120
  • Keywords: Cisplatin, Fluorouracil, Tumor markers

Abstract

Objective: In this study, we aimed to investigate the interference of 5-Fluorouracil (5-FU), cisplatin and their combination on laboratory results of CA 125, CA 15-3 and CA 19-9. Material and Methods: Blood samples were collected from ten volunteer donors who had not taken any medications. Each of these 10 blood samples were divided into four aliquots to form the control, 5-FU, cisplatin and 5-FU + cisplatin combination groups. Adequate amount of 5-FU, cisplatin and 5-FU + cisplatin combination, in accordance with maximum therapeutic plasma concentration, were added to aliquots. Serum CA 125 was determined by immunometric method, and CA 15-3 and CA 19-9 were determined by chemiluminescent immunometric method in each group. Results: Compared to control groups, we observed that 5-FU and cisplatin had positive interference effect on CA 125 and CA 19-9 laboratory results (p< 0.05), whereas no interference of these drugs was observed on CA 15-3 laboratory results (p> 0.05). Conclusion: We concluded that to obtain accurate laboratory results of tumor markers, interference of chemotherapeutic agents that were used to treat these patients should be considered. Copyright © 2006 by Türkiye Klinikleri.