Lorlatinib-Induced Blindness: A Rare Entity


Dincer N., Can O., Demir G., ÖZYAR E.

Practical Radiation Oncology, cilt.15, sa.2, ss.120-123, 2025 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 15 Sayı: 2
  • Basım Tarihi: 2025
  • Doi Numarası: 10.1016/j.prro.2025.01.004
  • Dergi Adı: Practical Radiation Oncology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, MEDLINE
  • Sayfa Sayıları: ss.120-123
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Evet

Özet

Lorlatinib is a central nervous system-penetrant third-generation tyrosine kinase inhibitor approved for the first-line management of metastatic non-small cell lung cancer with anaplastic lymphoma kinase rearrangement,1 which accounts for 3% to 5% of non-small cell lung cancer cases.2 The most commonly reported side effects include hyperlipidemia, edema, peripheral neuropathy, and central nervous system effects.2 Whereas ocular side effects such as photopsia, blurred vision, vitreous floaters, and diplopia have been documented with another anaplastic lymphoma kinase-tyrosine kinase inhibitor, crizotinib, there are few reports of such effects with lorlatinib.3 Herein, we present a case of bilateral optic neuropathy, initially misdiagnosed as optic nerve metastases and treated with palliative radiation therapy.