Estradiol increases apoptosis in human coronary artery endothelial cells by up-regulating fas and fas ligand expression


Seli E., Guzeloglu-Kayisli O., Cakmak H., Kayisli U. A. , Selam B. , Arici A.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, vol.91, no.12, pp.4995-5001, 2006 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 91 Issue: 12
  • Publication Date: 2006
  • Doi Number: 10.1210/jc.2006-1225
  • Title of Journal : JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
  • Page Numbers: pp.4995-5001

Abstract

Context: In animal models, estrogen inhibits atherogenesis by inhibiting many of the early steps of atherosclerotic plaque formation. However, the lack of cardioprotective effect by postmenopausal hormone replacement therapy and possible increase in cardiovascular events observed during the first year after the initiation of hormone replacement therapy may suggest that once the plaque is formed, estrogen may have additional effects that may counteract its beneficial outcomes. Indeed, the effect of estrogen on plaque stability has not been identified.