Monoglycoconjugated phthalocyanines: Effect of sugar and linkage on photodynamic activity

Lafont D., Zorlu Y., Savoie H., Albrieux F., Ahsen V., Boyle R. W., ...More

PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY, vol.10, no.3, pp.252-259, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 10 Issue: 3
  • Publication Date: 2013
  • Doi Number: 10.1016/j.pdpdt.2012.11.009
  • Journal Name: PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.252-259
  • Keywords: Photodynamic therapy, Photosensitiser, Phthalocyanine, Carbohydrate, Click chemistry, GLYCOCONJUGATED PORPHYRINS, CLICK-CHEMISTRY, THERAPY, PHOTOSENSITIZERS, DERIVATIVES, GLYCEROL
  • Acibadem Mehmet Ali Aydinlar University Affiliated: No

Abstract

Background: Click chemistry can be advantageously used to graft carbohydrates on phthalocyanines which are potent photosensitisers, but the effect of the presence of triazole moieties on photodynamic efficiency was not investigated systematically to date. The nature and linkage of the sugar were investigated in order to define structure activity relationships.