Effect of magnesium supplementation and depletion on the onset and course of acute experimental pancreatitis

Schick, Verena; Scheiber, Jonas; Mooren, Frank; Turi, Stefan; Ceyhan, GÜRALP; Schnekenburger, Juergen; Sendler, Matthias; Schwaiger, Theresa; Omercevic, Armin; van den Brandt, Cindy; Fluhr, Gabriele; Domschke, Wolfram; Krueger, Burkhard; Mayerle, Julia; Lerch, Markus

doi:10.1136/gutjnl-2012-304274

Effect of magnesium supplementation and depletion on the onset and course of acute experimental pancreatitis

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Schick V., Scheiber J. A., Mooren F. C., Turi S., Ceyhan G., Schnekenburger J., ...More

GUT, vol.63, no.9, pp.1469-1480, 2014 (SCI-Expanded)

Publication Type: Article / Article
Volume: 63 Issue: 9
Publication Date: 2014
Doi Number: 10.1136/gutjnl-2012-304274
Journal Name: GUT
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.1469-1480
Acibadem Mehmet Ali Aydinlar University Affiliated: No

Abstract

Background and objective High calcium concentrations are an established risk factor for pancreatitis. We have investigated whether increasing magnesium concentrations affect pathological calcium signals and premature protease activation in pancreatic acini, and whether dietary or intraperitoneal magnesium administration affects the onset and course of experimental pancreatitis.