A rare clinical presentation: a pleomorphic xanthoastrocytoma presenting with intracerebral haemorrhage and metastasizing vigorouslycase report and review of the literature

Otluoglu G. D. , Ozek M. M.

CHILDS NERVOUS SYSTEM, vol.35, no.2, pp.355-362, 2019 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 35 Issue: 2
  • Publication Date: 2019
  • Doi Number: 10.1007/s00381-018-3960-1
  • Journal Indexes: Science Citation Index Expanded
  • Page Numbers: pp.355-362
  • Keywords: Pleomorphic xanthoastrocytoma, Haemorrhage, Anaplastic PXA, Lesion, MALIGNANT-TRANSFORMATION, FEATURES, GLIOBLASTOMA, PROGRESSION, OUTCOMES, PATIENT


Metastasis of an intracranial tumour is not a common situation in our daily neurosurgical practice. Pleomorphic xanthoastrocytoma is also a rare glial tumour with relatively a favourable prognosis among other CNS pathologies. Here, we present an anaplastic pleomorphic xanthoastrocytoma case which shows both haematogenous and lymphatic metastasis which is described first time in the up-to-date literature. Our case is a 17-year-old male operated for a right occipital intra-axial lesion with a diagnosis of anaplastic pleomorphic xanthoastrocytoma which recurs 5years later and metastasize vigorously through haematogenous and lymphatic routes. A rare-presenting symptom for this pathology is also intracerebral haemorrhage. This is the ninth case report in the literature which presents initially with this entity.