Induction of spermatogenesis by inguinal varicocele repair in azoospermic men

Cakan M., Altug U.

ARCHIVES OF ANDROLOGY, vol.50, no.3, pp.145-150, 2004 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 50 Issue: 3
  • Publication Date: 2004
  • Doi Number: 10.1080/01485010490425250
  • Journal Name: ARCHIVES OF ANDROLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.145-150
  • Keywords: azoospermia, induction, spermatogenesis, varicocele repair, INTRACYTOPLASMIC SPERM INJECTION, NONOBSTRUCTIVE AZOOSPERMIA, INFERTILITY, FERTILIZATION, PARAMETERS, PREGNANCY, FERTILITY, SEMEN
  • Acibadem Mehmet Ali Aydinlar University Affiliated: No

Abstract

13 infertile patients who had complete azoospermia and clinical varicocele underwent inguinal varicocele repair. Semen analyses were obtained starting 3 months after varicocele repair. Bilateral varicocele repair in 2 men and unilateral in 11 men were performed. Induction of spermatogenesis was achieved in 3 (23%) patients. Two of them had hypospermatogenesis and one had maturation arrest at spermatid stage. No pregnancies by natural intercourse resulted. Although one couple used fresh ejaculate for intracytoplasmic sperm injection, the result was unsuccessful. All men with Sertoli cell-only and early maturation arrest remained azoospermic after surgery. No association between successful outcome and patient age, sex hormone analysis, varicocele grade, testicular volume, unilateral or bilateral varicocele repair were apparent. Varicocele repair can result in the induction of spermatogenesis for men with hypospermatogenesis and late maturation arrest. No other related factor could be detected.