Nuhoğlu D., Guney Kekec G., Senturk B., Karadeniz K. B., Camadan E. E. I., Pendar A., ...Daha Fazla
ACS OMEGA, cilt.602983, ss.1-9, 2026 (SCI-Expanded, Scopus)
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Yayın Türü:
Makale / Tam Makale
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Cilt numarası:
602983
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Basım Tarihi:
2026
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Doi Numarası:
10.1021/acsomega.6c02983
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Dergi Adı:
ACS OMEGA
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Derginin Tarandığı İndeksler:
Scopus, Science Citation Index Expanded (SCI-EXPANDED), Chemical Abstracts Core, Directory of Open Access Journals
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Sayfa Sayıları:
ss.1-9
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Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli:
Evet
Özet
Copeptin is an important biomarker for the diagnosis of acute myocardial infarction in the troponin-blind period. In this study, a peptide-based nanostructured electrochemical biosensor was developed on a screen-printed electrode platform, enabling a disposable sensing strategy suitable for on-site applications. A copeptin-specific peptide, synthesized for this study, was employed as the biorecognition element to provide binding sites for the target. The UiO-66-NH2 metal–organic framework was synthesized to improve the electrochemical response and served as a functional interface due to its high surface area. The proposed biosensor platform provides a sensitive detection of copeptin with a limit of detection of 228.5 pg/mL, offering a promising low-cost and efficient peptide-based electrochemical sensing platform.