Nanostructured Electrochemical Biosensor for Highly Sensitive Copeptin Detection as a Cardiac Biomarker
ACS OMEGA, 2026 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Publication Date: 2026
- Doi Number: 10.1021/acsomega.6c02983
- Journal Name: ACS OMEGA
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Chemical Abstracts Core, Directory of Open Access Journals
- Acibadem Mehmet Ali Aydinlar University Affiliated: Yes
Abstract
Copeptin is an important biomarker for the diagnosis of acute myocardial infarction in the troponin-blind period. In this study, a peptide-based nanostructured electrochemical biosensor was developed on a screen-printed electrode platform, enabling a disposable sensing strategy suitable for on-site applications. A copeptin-specific peptide, synthesized for this study, was employed as the biorecognition element to provide binding sites for the target. The UiO-66-NH2 metal-organic framework was synthesized to improve the electrochemical response and served as a functional interface due to its high surface area. The proposed biosensor platform provides a sensitive detection of copeptin with a limit of detection of 228.5 pg/mL, offering a promising low-cost and efficient peptide-based electrochemical sensing platform.