Mediastinal adipose tissue expresses a pathogenic profile of 11 β-hydroxysteroid dehydrogenase Type 1, glucocorticoid receptor, and CD68 in patients with coronary artery disease.

ATALAR F., Gormez S., Caynak B., Akan G., Tanriverdi G., Bilgic-Gazioglu S., ...Daha Fazla

Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology, cilt.22, sa.3, ss.183-8, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 22 Sayı: 3
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1016/j.carpath.2012.07.006
  • Dergi Adı: Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.183-8
  • Anahtar Kelimeler: Mediastinal adipose tissue, Subcutaneous adipose tissue, 11 beta hydroxysteroid dehydrogenase, Glucocorticoid receptor, Coronary artery disease, VISCERAL ABDOMINAL FAT, CARDIOVASCULAR-DISEASE, PERICARDIAL FAT, CARDIOMETABOLIC RISK, METABOLIC SYNDROME, EPICARDIAL FAT, OBESITY, HEART, INFLAMMATION, RESISTANCE
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

Objective: Cardiac visceral fat is accepted to be a new marker for cardiometabolic risk due to its association with increased cardiovascular risk factors. This study aimed to compare the expression of 11 beta hydroxysteroid dehydrogenases (11 beta-HSD)-1, glucocorticoid receptor (GCR), and CD68 in mediastinal and subcutaneous adipose tissues (MAT, and SAT, respectively) and to assess their possible relationships with the development of coronary artery disease (CAD).