bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM)the active metabolite of the laxatives bisacodyl and sodium picosulfateenhances contractility and secretion in human intestine in vitro

Krueger, D.; Demir, I.; Ceyhan, GÜRALP; Zeller, F.; Schemann, M.

doi:10.1111/nmo.13311

bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM)the active metabolite of the laxatives bisacodyl and sodium picosulfateenhances contractility and secretion in human intestine in vitro

Atıf İçin Kopyala

Krueger D., Demir I. E., Ceyhan G. O., Zeller F., Schemann M.

NEUROGASTROENTEROLOGY AND MOTILITY, cilt.30, sa.7, 2018 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 30 Sayı: 7
Basım Tarihi: 2018
Doi Numarası: 10.1111/nmo.13311
Dergi Adı: NEUROGASTROENTEROLOGY AND MOTILITY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Anahtar Kelimeler: bis-(p-hydroxyphenyl)-pyridyl-2-methane, laxative, motility, secretion, IBEROGAST(R), CONSTIPATION, ELECTROLYTE, MECHANISM, TRANSPORT, TRANSIT, COLON, WATER
Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

BackgroundStimulant laxatives are widely used to treat constipation. We investigated in human small and large intestinal preparations the effects of bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM), the active metabolite of the laxatives bisacodyl and sodium picosulfate on smooth muscle tone and epithelial secretion.