bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM)the active metabolite of the laxatives bisacodyl and sodium picosulfateenhances contractility and secretion in human intestine in vitro


Krueger D., Demir I. E. , Ceyhan G. O. , Zeller F., Schemann M.

NEUROGASTROENTEROLOGY AND MOTILITY, vol.30, no.7, 2018 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 30 Issue: 7
  • Publication Date: 2018
  • Doi Number: 10.1111/nmo.13311
  • Title of Journal : NEUROGASTROENTEROLOGY AND MOTILITY

Abstract

BackgroundStimulant laxatives are widely used to treat constipation. We investigated in human small and large intestinal preparations the effects of bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM), the active metabolite of the laxatives bisacodyl and sodium picosulfate on smooth muscle tone and epithelial secretion.