GRANULOSA CELLS OF WOMEN WITH PCOS WITH OR WITHOUT INSULIN RESISTANCE DISPLAY SIGNS OF METABOLIC DISTRESS


Cozzolino M., Herraiz S., Cakıroglu A. Y. , Tıraş M. , Velasco J. G. , Pacheco A., ...More

ASRM Scientific Congress & Expo 2021, Maryland, United States Of America, 24 - 27 October 2021, vol.116, no.3, pp.84

  • Publication Type: Conference Paper / Summary Text
  • Volume: 116
  • City: Maryland
  • Country: United States Of America
  • Page Numbers: pp.84

Abstract

PCOS is diagnosed based on the presence of oligo/anovulation, hyperandrogenemia/hyperandrogenism, and polycystic ovaries. In addition, many women with PCOS have hyperinsulinemia and insulin resistance (IR), which are associated with significant cellular metabolic abnormalities. In this study, we investigated whether metabolic dysfunction in women with PCOS induces granulosa cell stress and causes activation of endoplasmic reticulum and mitochondrial unfolded protein response (UPR er and UPR mt).