GRANULOSA CELLS OF WOMEN WITH PCOS WITH OR WITHOUT INSULIN RESISTANCE DISPLAY SIGNS OF METABOLIC DISTRESS

Cozzolino M., Herraiz S., Cakıroglu A. Y., Tıraş M., Velasco J. G., Pacheco A., ...Daha Fazla

ASRM Scientific Congress & Expo 2021, Maryland, Amerika Birleşik Devletleri, 24 - 27 Ekim 2021, cilt.116, sa.3, ss.84

  • Yayın Türü: Bildiri / Özet Bildiri
  • Cilt numarası: 116
  • Basıldığı Şehir: Maryland
  • Basıldığı Ülke: Amerika Birleşik Devletleri
  • Sayfa Sayıları: ss.84
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Evet

Özet

PCOS is diagnosed based on the presence of oligo/anovulation, hyperandrogenemia/hyperandrogenism, and polycystic ovaries. In addition, many women with PCOS have hyperinsulinemia and insulin resistance (IR), which are associated with significant cellular metabolic abnormalities. In this study, we investigated whether metabolic dysfunction in women with PCOS induces granulosa cell stress and causes activation of endoplasmic reticulum and mitochondrial unfolded protein response (UPR er and UPR mt).