Time course of collagen peak in bile duct-ligated rats


Tarcin O., Basaranoglu M., Tahan V., Tahan G., Sucullu I., Yilmaz N., ...More

BMC GASTROENTEROLOGY, vol.11, 2011 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 11
  • Publication Date: 2011
  • Doi Number: 10.1186/1471-230x-11-45
  • Journal Name: BMC GASTROENTEROLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: Bile duct-ligated rat, fibrosis, fibrogenesis, liver, collagen, reversible, BILIARY-OBSTRUCTED RATS, INDUCED LIVER FIBROSIS, HEPATIC-FIBROSIS, INTERFERON-ALPHA, VITAMIN-E, DAMAGE, PROLIDASE, CIRRHOSIS, INJURY, MODEL
  • Acibadem Mehmet Ali Aydinlar University Affiliated: Yes

Abstract

Background: One of the most useful experimental fibrogenesis models is the "bile duct-ligated rats". Our aim was to investigate the quantitative hepatic collagen content by two different methods during the different stages of hepatic fibrosis in bile duct-ligated rats on a weekly basis. We questioned whether the 1-wk or 4-wk bile duct-ligated model is suitable in animal fibrogenesis trials.