Time course of collagen peak in bile duct-ligated rats

Tarcin, Orhan; Basaranoglu, Metin; Tahan, Veysel; Tahan, Gulgun; Sucullu, Ilker; Yilmaz, Nevin; Sood, Gagan; Snyder, Ned; Hilman, Gilbert; ÇELİKEL, ÇİĞDEM; Tozun, AYŞE

doi:10.1186/1471-230x-11-45

Time course of collagen peak in bile duct-ligated rats

Tarcin O., Basaranoglu M., Tahan V., Tahan G., Sucullu I., Yilmaz N., ...Daha Fazla

BMC GASTROENTEROLOGY, cilt.11, 2011 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 11
Basım Tarihi: 2011
Doi Numarası: 10.1186/1471-230x-11-45
Dergi Adı: BMC GASTROENTEROLOGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Anahtar Kelimeler: Bile duct-ligated rat, fibrosis, fibrogenesis, liver, collagen, reversible, BILIARY-OBSTRUCTED RATS, INDUCED LIVER FIBROSIS, HEPATIC-FIBROSIS, INTERFERON-ALPHA, VITAMIN-E, DAMAGE, PROLIDASE, CIRRHOSIS, INJURY, MODEL
Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Evet

Özet

Background: One of the most useful experimental fibrogenesis models is the "bile duct-ligated rats". Our aim was to investigate the quantitative hepatic collagen content by two different methods during the different stages of hepatic fibrosis in bile duct-ligated rats on a weekly basis. We questioned whether the 1-wk or 4-wk bile duct-ligated model is suitable in animal fibrogenesis trials.