Neoadjuvant Therapy Remodels the Pancreatic Cancer Microenvironment via Depletion of Protumorigenic Immune Cells


Reyes C. M. , Teller S., Muckenhuber A., Konukiewitz B., Safak O., Weichert W., ...More

CLINICAL CANCER RESEARCH, vol.26, no.1, pp.220-231, 2020 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 26 Issue: 1
  • Publication Date: 2020
  • Doi Number: 10.1158/1078-0432.ccr-19-1864
  • Title of Journal : CLINICAL CANCER RESEARCH
  • Page Numbers: pp.220-231

Abstract

Purpose: Neoadjuvant therapy (neoTx) has dramatically improved the prognosis of patients with locally advanced and borderline resectable pancreatic ductal adenocarcinoma, yet its mechanisms of action on tumor cells and the tumor microenvironment are still unknown. Here, we aimed to characterize the multiple facets of neoTx-induced alterations in the pancreatic cancer microenvironment.