Neoadjuvant Therapy Remodels the Pancreatic Cancer Microenvironment via Depletion of Protumorigenic Immune Cells


Reyes C. M. , Teller S., Muckenhuber A., Konukiewitz B., Safak O., Weichert W., ...Daha Fazla

CLINICAL CANCER RESEARCH, cilt.26, sa.1, ss.220-231, 2020 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 26 Konu: 1
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1158/1078-0432.ccr-19-1864
  • Dergi Adı: CLINICAL CANCER RESEARCH
  • Sayfa Sayıları: ss.220-231

Özet

Purpose: Neoadjuvant therapy (neoTx) has dramatically improved the prognosis of patients with locally advanced and borderline resectable pancreatic ductal adenocarcinoma, yet its mechanisms of action on tumor cells and the tumor microenvironment are still unknown. Here, we aimed to characterize the multiple facets of neoTx-induced alterations in the pancreatic cancer microenvironment.