Design and evaluation of innovative nanohybrids: porphyrin-loaded PEG-GO/AgNp systems for PDT
INORGANIC CHEMISTRY COMMUNICATION, cilt.183, ss.115718, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 183
- Basım Tarihi: 2026
- Doi Numarası: 10.1016/j.inoche.2025.115718
- Dergi Adı: INORGANIC CHEMISTRY COMMUNICATION
- Derginin Tarandığı İndeksler: Scopus, Science Citation Index Expanded (SCI-EXPANDED), Academic Search Premier, Chemical Abstracts Core, Chimica, DIALNET
- Sayfa Sayıları: ss.115718
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Evet
Özet
PEGylated graphene oxide (PEG-GO) and silver nanoparticles (AgNPs) were utilized to create hybrid nanocomposite structures. Porphyrin was selected based on its substitution pattern, which is suitable for photodynamic therapy (PDT). An electron-withdrawing -NO 2 group and an electron-donating -NH 2 group were chosen as substituents on porphyrin to compare their effects on singlet oxygen generation. PEG-GO-Ag hybrid nanocomposite structures with porphyrin were produced using the electrospinning method. The incorporation of Zn metal enhanced the spin-orbit coupling between the metal ion d-orbitals and the porphyrin π-system, potentially increasing singlet oxygen generation. Eight sets of hybrid nanocomposites were obtained. The singlet oxygen quantum yield values increased in the order from NO 2 complexes to NH 2 complexes. PEG-GO-Ag-Zn-Tetra/NH 2 exhibited a singlet oxygen generation value of 0.59, the highest observed, indicating it as the most promising photosensitizer for improved photodynamic efficiency.