Role of FLT3 in the proliferation and aggressiveness of hepatocellular carcinoma


Aydin M. M. , Bayin N. S. , ACUN T., YAKICIER M. C. , AKÇALI K. C.

TURKISH JOURNAL OF MEDICAL SCIENCES, vol.46, no.2, pp.572-581, 2016 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 46 Issue: 2
  • Publication Date: 2016
  • Doi Number: 10.3906/sag-1501-173
  • Title of Journal : TURKISH JOURNAL OF MEDICAL SCIENCES
  • Page Numbers: pp.572-581

Abstract

Background/aim: Previously we showed that Fms-like tyrosine kinase (FLT3) changes its cellular localization upon partial hepatectomy, suggesting a role in liver regeneration. FLT3 was also shown to play an important function in cellular proliferation and activation of PI3K and Ras. Thus, we aimed to investigate the role of FLT3 in hepatocellular tumorigenesis utilizing in vitro and in vivo models.