Vitamin E protects against the development of radiation-induced pulmonary fibrosis in rats
CLINICAL ONCOLOGY, vol.19, no.4, pp.260-264, 2007 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 19 Issue: 4
- Publication Date: 2007
- Doi Number: 10.1016/j.clon.2006.12.007
- Journal Name: CLINICAL ONCOLOGY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.260-264
- Keywords: alpha-tocopherol, pentoxifylline, pulmonary fibrosis, radiation, vitamin E, INDUCED LUNG, COMBINED PENTOXIFYLLINE, STRIKING REGRESSION, NORMAL TISSUE, PNEUMONITIS, INJURY, DAMAGE, COMBINATION, PARAMETERS, TOCOPHEROL
- Acibadem Mehmet Ali Aydinlar University Affiliated: No
Abstract
Aims: To investigate whether the application of vitamin E with or without pentoxifylline could modify the development of radiation-induced pulmonary fibrosis. Materials and methods: Wistar albino rats were supplemented with either vitamin E or pentoxifylline or with both vitamin E and pentoxifylline after a single dose of 14 Gy thoracic irradiation. Supplementation was started the day after irradiation and continued until the rats were sacrificed. As a quantitative end point, the extent of fibrosis was evaluated with a scale from 0 (normal lung) to 8 (total fibrous obliteration of the field) at pathological examination of the lung tissue. Results: A significant reduction in fibrosis was obtained in the group of rats supplemented with vitamin E with or without pentoxifylline, when compared with the group that had irradiation only. Conclusion: This experimental study showed that vitamin E supplementation immediately after irradiation protected rats against radiation-induced pulmonary fibrosis. The combination with pentoxifylline was more effective, although pentoxifylline itself had limited efficacy, which was not statistically significant.