Vitamin E protects against the development of radiation-induced pulmonary fibrosis in rats

Bese N. S., Munzuroglu F., Uslu B., Arbak S., Yesiladali G., Sut N., ...Daha Fazla

CLINICAL ONCOLOGY, cilt.19, sa.4, ss.260-264, 2007 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 19 Sayı: 4
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1016/j.clon.2006.12.007
  • Dergi Adı: CLINICAL ONCOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.260-264
  • Anahtar Kelimeler: alpha-tocopherol, pentoxifylline, pulmonary fibrosis, radiation, vitamin E, INDUCED LUNG, COMBINED PENTOXIFYLLINE, STRIKING REGRESSION, NORMAL TISSUE, PNEUMONITIS, INJURY, DAMAGE, COMBINATION, PARAMETERS, TOCOPHEROL
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

Aims: To investigate whether the application of vitamin E with or without pentoxifylline could modify the development of radiation-induced pulmonary fibrosis. Materials and methods: Wistar albino rats were supplemented with either vitamin E or pentoxifylline or with both vitamin E and pentoxifylline after a single dose of 14 Gy thoracic irradiation. Supplementation was started the day after irradiation and continued until the rats were sacrificed. As a quantitative end point, the extent of fibrosis was evaluated with a scale from 0 (normal lung) to 8 (total fibrous obliteration of the field) at pathological examination of the lung tissue. Results: A significant reduction in fibrosis was obtained in the group of rats supplemented with vitamin E with or without pentoxifylline, when compared with the group that had irradiation only. Conclusion: This experimental study showed that vitamin E supplementation immediately after irradiation protected rats against radiation-induced pulmonary fibrosis. The combination with pentoxifylline was more effective, although pentoxifylline itself had limited efficacy, which was not statistically significant.