Genetic Variants in the <i>PNPLA3</i> Gene Are Associated with Nonalcoholic Steatohepatitis

Islek E. E., Sazci A., Ozel M. D., Aygun C.

GENETIC TESTING AND MOLECULAR BIOMARKERS, cilt.18, sa.7, ss.489-496, 2014 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 18 Sayı: 7
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1089/gtmb.2014.0019
  • Dergi Adı: GENETIC TESTING AND MOLECULAR BIOMARKERS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.489-496
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

In this study, we report the association of the rs738407, rs738409, and rs2896019 variants of the patatin-like phospholipase domain-containing protein 3 (PNPLA3) (adiponutrin) gene with nonalcoholic steatohepatitis (NASH) (chi(2) = 14.528, p = 0.001; chi(2) = 18.882, p = 0.000; chi(2) = 7.449, p = 0.024, respectively) in 80 patients with NASH and 303 healthy controls. We genotyped the subjects using three polymerase chain reaction-restriction fragment length polymorphism methods developed in our laboratory. Our findings confirm the findings of the recent case-control and genome-wide association studies carried out in different populations around the world. Thus, the three variants in PNPLA3 gene may be a genetic risk factor for NASH.