Iron preloading aggravates nutritional steatohepatitis in rats by increasing apoptotic cell death

Imeryuz, Nese; Tahan, Veysel; SONSUZ, ABDULLAH; EREN, FATİH; Uraz, Suleyman; YÜKSEL, MERAL; Akpulat, Sertac; Ozcelik, Dervis; Haklar, Goncagul; Celike, Cigdem; Avsar, Erol; Tozun, Ayşe

doi:10.1016/j.jhep.2007.06.018

Iron preloading aggravates nutritional steatohepatitis in rats by increasing apoptotic cell death

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Imeryuz N., Tahan V., SONSUZ A., EREN F., Uraz S., YÜKSEL M., ...More

JOURNAL OF HEPATOLOGY, vol.47, no.6, pp.851-859, 2007 (SCI-Expanded)

Publication Type: Article / Article
Volume: 47 Issue: 6
Publication Date: 2007
Doi Number: 10.1016/j.jhep.2007.06.018
Journal Name: JOURNAL OF HEPATOLOGY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.851-859
Keywords: liver fibrosis, methionine and choline deficient diet, necroinflammation, reactive oxygen species, nonalcoholic steatohepatitis, MITOCHONDRIAL PERMEABILITY TRANSITION, NONALCOHOLIC STEATOHEPATITIS, HEPATIC IRON, FATTY LIVER, HEPATOCYTE APOPTOSIS, LIPID-PEROXIDATION, PROTEIN ADDUCTS, IN-VIVO, MODEL, FIBROSIS
Acibadem Mehmet Ali Aydinlar University Affiliated: No

Abstract

Background/Aims: High serum ferritin and liver iron concentrations were found in some patients with NASH, suggesting a role for iron as a co-factor that aggravates liver injury. The aim of this study is to investigate the effects of parenteral iron in a rat model of NASH induced by a methionine choline deficient diet (MCDD).