Iron preloading aggravates nutritional steatohepatitis in rats by increasing apoptotic cell death

Imeryuz, Nese; Tahan, Veysel; SONSUZ, ABDULLAH; EREN, FATİH; Uraz, Suleyman; YÜKSEL, MERAL; Akpulat, Sertac; Ozcelik, Dervis; Haklar, Goncagul; Celike, Cigdem; Avsar, Erol; Tozun, AYŞE

doi:10.1016/j.jhep.2007.06.018

Iron preloading aggravates nutritional steatohepatitis in rats by increasing apoptotic cell death

Imeryuz N., Tahan V., SONSUZ A., EREN F., Uraz S., YÜKSEL M., ...Daha Fazla

JOURNAL OF HEPATOLOGY, cilt.47, sa.6, ss.851-859, 2007 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 47 Sayı: 6
Basım Tarihi: 2007
Doi Numarası: 10.1016/j.jhep.2007.06.018
Dergi Adı: JOURNAL OF HEPATOLOGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.851-859
Anahtar Kelimeler: liver fibrosis, methionine and choline deficient diet, necroinflammation, reactive oxygen species, nonalcoholic steatohepatitis, MITOCHONDRIAL PERMEABILITY TRANSITION, NONALCOHOLIC STEATOHEPATITIS, HEPATIC IRON, FATTY LIVER, HEPATOCYTE APOPTOSIS, LIPID-PEROXIDATION, PROTEIN ADDUCTS, IN-VIVO, MODEL, FIBROSIS
Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

Background/Aims: High serum ferritin and liver iron concentrations were found in some patients with NASH, suggesting a role for iron as a co-factor that aggravates liver injury. The aim of this study is to investigate the effects of parenteral iron in a rat model of NASH induced by a methionine choline deficient diet (MCDD).