Iron preloading aggravates nutritional steatohepatitis in rats by increasing apoptotic cell death

Imeryuz N., Tahan V., SONSUZ A., EREN F., Uraz S., YÜKSEL M., ...More

JOURNAL OF HEPATOLOGY, vol.47, no.6, pp.851-859, 2007 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 47 Issue: 6
  • Publication Date: 2007
  • Doi Number: 10.1016/j.jhep.2007.06.018
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.851-859
  • Keywords: liver fibrosis, methionine and choline deficient diet, necroinflammation, reactive oxygen species, nonalcoholic steatohepatitis, MITOCHONDRIAL PERMEABILITY TRANSITION, NONALCOHOLIC STEATOHEPATITIS, HEPATIC IRON, FATTY LIVER, HEPATOCYTE APOPTOSIS, LIPID-PEROXIDATION, PROTEIN ADDUCTS, IN-VIVO, MODEL, FIBROSIS
  • Acibadem Mehmet Ali Aydinlar University Affiliated: No


Background/Aims: High serum ferritin and liver iron concentrations were found in some patients with NASH, suggesting a role for iron as a co-factor that aggravates liver injury. The aim of this study is to investigate the effects of parenteral iron in a rat model of NASH induced by a methionine choline deficient diet (MCDD).