Can the classical euchromatic variants of 9q12/qh+ cause recurrent abortions?

Dundar M., Caglayan A. O., Saatci C., Batukan C., Basbug M., Ozkul Y.

Genetic counseling (Geneva, Switzerland), cilt.19, sa.3, ss.281-6, 2008 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 19 Sayı: 3
  • Basım Tarihi: 2008
  • Dergi Adı: Genetic counseling (Geneva, Switzerland)
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.281-6
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

Can the classical euchromatic variants of 9q12/qh+ cause recurrent abortions?: Various heteromorphisms of the 9q heterochromatic area have been reported, and the 9q12/qh varient has been postulated to be more prevalent than initially perceived. Of note is that all probands are clinically normal. This paper documents two cases with a G-band within the 9q12h region and recurrent miscarriages. Patient 1 is a 22-year-old woman with a history of 2 miscarriages. Patient 2 is a 19-year-old woman with a history of 3 miscarriages. Chromosome analysis of the patients showed 46,XX,9q12h+. Thus, the existence of a G+ band in 9qh may not be a normal variant in humans. We suggest IVF and preimplantation genetic diagnosis in such patients.