Seizure expression, behavior, and brain morphology differences in colonies of Genetic Absence Epilepsy Rats from Strasbourg

Powell K. L., Tang H., Ng C., Guillemain I., Dieuset G., Dezsi G., ...Daha Fazla

EPILEPSIA, cilt.55, sa.12, ss.1959-1968, 2014 (SCI-Expanded) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 55 Sayı: 12
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1111/epi.12840
  • Dergi Adı: EPILEPSIA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1959-1968
  • Anahtar Kelimeler: Genetic absence epilepsy rat from Strasbourg, Absence seizures, Behavioral comorbidities, Brain morphology, Ca(V)3, 2 R1584P mutation, Cacna1h, GENERALIZED EPILEPSY, WAVE DISCHARGES, PAROXYSMAL OSCILLATIONS, MODEL, CACNA1H, NEURONS, GAERS, COMORBIDITY, VARIANTS, ANXIETY
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

ObjectiveOriginally derived from a Wistar rat strain, a proportion of which displayed spontaneous absence-type seizures, Genetic Absence Epilepsy Rats from Strasbourg (GAERS) represent the most widely utilized animal model of genetic generalized epilepsy. Here we compare the seizure, behavioral, and brain morphometric characteristics of four main GAERS colonies that are being actively studied internationally: two from Melbourne (MELB and STRAS-MELB), one from Grenoble (GREN), and one from Istanbul (ISTAN).