Seizure expression, behavior, and brain morphology differences in colonies of Genetic Absence Epilepsy Rats from Strasbourg


Powell K. L. , Tang H., Ng C., Guillemain I., Dieuset G., Dezsi G., ...More

EPILEPSIA, vol.55, no.12, pp.1959-1968, 2014 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 55 Issue: 12
  • Publication Date: 2014
  • Doi Number: 10.1111/epi.12840
  • Title of Journal : EPILEPSIA
  • Page Numbers: pp.1959-1968
  • Keywords: Genetic absence epilepsy rat from Strasbourg, Absence seizures, Behavioral comorbidities, Brain morphology, Ca(V)3, 2 R1584P mutation, Cacna1h, GENERALIZED EPILEPSY, WAVE DISCHARGES, PAROXYSMAL OSCILLATIONS, MODEL, CACNA1H, NEURONS, GAERS, COMORBIDITY, VARIANTS, ANXIETY

Abstract

ObjectiveOriginally derived from a Wistar rat strain, a proportion of which displayed spontaneous absence-type seizures, Genetic Absence Epilepsy Rats from Strasbourg (GAERS) represent the most widely utilized animal model of genetic generalized epilepsy. Here we compare the seizure, behavioral, and brain morphometric characteristics of four main GAERS colonies that are being actively studied internationally: two from Melbourne (MELB and STRAS-MELB), one from Grenoble (GREN), and one from Istanbul (ISTAN).