SOX1 antibodies are markers of paraneoplastic Lambert-Eaton myasthenic syndrome

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Sabater L., Titulaer M., Saiz A., Verschuuren J., Guere A. O. , Graus F.

NEUROLOGY, vol.70, no.12, pp.924-928, 2008 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 70 Issue: 12
  • Publication Date: 2008
  • Doi Number: 10.1212/01.wnl.0000281663.81079.24
  • Title of Journal : NEUROLOGY
  • Page Numbers: pp.924-928


Background/Objective: We reported that 43% of patients with Lambert-Eaton myasthenic syndrome (LEMS) and small cell lung cancer (SCLC) had an antibody called anti-glial nuclear antibody (AGNA), defined by the immunoreaction with the nuclei of the Bergmann glia of the cerebellum. This study was undertaken to identify the antigen recognized by AGNA and to confirm the association with paraneoplastic LEMS in a larger series.