The effects of hyperthermic intraperitoneal chemoperfusion on colonic anastomosis: an experimental study in a rat model


Aghayeva A., Benlice C., Bilgin I. A. , Atukeren P., Dogusoy G., Demir F. , et al.

TUMORI J, cilt.103, ss.307-313, 2017 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 103 Konu: 3
  • Basım Tarihi: 2017
  • Doi Numarası: 10.5301/tj.5000610
  • Dergi Adı: TUMORI J
  • Sayfa Sayısı: ss.307-313

Özet

Introduction: Cytoreductive surgery (CRS) with subsequent hyperthermic intraperitoneal chemotherapy (HIPEC) is a promising modality to treat and prevent peritoneal metastases. However, this treatment is associated with signficant morbidity and mortality. Whether or not CRS with HIPEC interferes with anastomotic healing has also been debated. This study was designed to investigate the effects of mitomycin C, cisplatin, oxaliplatin, and doxorubicin used in HIPEC treatment on colonic anastomosis healing in a rat model.