The effects of hyperthermic intraperitoneal chemoperfusion on colonic anastomosis: an experimental study in a rat model.


Aghayeva A. , Benlice C., Bilgin İ. A. , Atukeren P., Dogusoy G., Demir F. , ...More

Tumori, vol.103, no.3, pp.307-313, 2017 (Journal Indexed in SCI Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 103 Issue: 3
  • Publication Date: 2017
  • Doi Number: 10.5301/tj.5000610
  • Title of Journal : Tumori
  • Page Numbers: pp.307-313
  • Keywords: Anastomosis, Chemoperfusion, Colon, HIPEC, Hyperthermic intraperitoneal chemotherapy, STIMULATING FACTOR IMPROVES, LONG-TERM SURVIVAL, PERITONEAL CARCINOMATOSIS, CYTOREDUCTIVE SURGERY, PSEUDOMYXOMA PERITONEI, ANTERIOR RESECTION, COLORECTAL-CANCER, RISK-FACTORS, CHEMOTHERAPY, LEAKAGE

Abstract

Introduction: Cytoreductive surgery (CRS) with subsequent hyperthermic intraperitoneal chemotherapy (HIPEC) is a promising modality to treat and prevent peritoneal metastases. However, this treatment is associated with signficant morbidity and mortality. Whether or not CRS with HIPEC interferes with anastomotic healing has also been debated. This study was designed to investigate the effects of mitomycin C, cisplatin, oxaliplatin, and doxorubicin used in HIPEC treatment on colonic anastomosis healing in a rat model.