The effects of hyperthermic intraperitoneal chemoperfusion on colonic anastomosis: an experimental study in a rat model.

Aghayeva A., Benlice C., Bilgin İ. A., Atukeren P., Dogusoy G., Demir F., ...Daha Fazla

Tumori, cilt.103, sa.3, ss.307-313, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 103 Sayı: 3
  • Basım Tarihi: 2017
  • Doi Numarası: 10.5301/tj.5000610
  • Dergi Adı: Tumori
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.307-313
  • Anahtar Kelimeler: Anastomosis, Chemoperfusion, Colon, HIPEC, Hyperthermic intraperitoneal chemotherapy, STIMULATING FACTOR IMPROVES, LONG-TERM SURVIVAL, PERITONEAL CARCINOMATOSIS, CYTOREDUCTIVE SURGERY, PSEUDOMYXOMA PERITONEI, ANTERIOR RESECTION, COLORECTAL-CANCER, RISK-FACTORS, CHEMOTHERAPY, LEAKAGE
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Evet

Özet

Introduction: Cytoreductive surgery (CRS) with subsequent hyperthermic intraperitoneal chemotherapy (HIPEC) is a promising modality to treat and prevent peritoneal metastases. However, this treatment is associated with signficant morbidity and mortality. Whether or not CRS with HIPEC interferes with anastomotic healing has also been debated. This study was designed to investigate the effects of mitomycin C, cisplatin, oxaliplatin, and doxorubicin used in HIPEC treatment on colonic anastomosis healing in a rat model.