Angio-oedema as an unusual tolerable side effect of voriconazole therapy

Gencer S., Ozer S., Demirhan G., Ak Ö., Batirel A.

JOURNAL OF MEDICAL MICROBIOLOGY, vol.57, no.8, pp.1028-1031, 2008 (SCI-Expanded) identifier identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 57 Issue: 8
  • Publication Date: 2008
  • Doi Number: 10.1099/jmm.0.47299-0
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED)
  • Page Numbers: pp.1028-1031
  • Acibadem Mehmet Ali Aydinlar University Affiliated: No


Voriconazole (VRC) has not previously been reported to cause angio-oedema. Here, we report a case of angio-oedema associated with VRC therapy. A 37-year-old woman with relapsing invasive vertebral aspergillosis received intravenous VRC and developed angio-oedema 10 days after starting therapy. This condition rapidly diminished after administration of intravenous antihistaminics and did not necessitate cessation of VRC treatment. The treatment was continued for 6 months without recurrence of the symptoms. After 18 months, the patient was in good health. To our knowledge, this is the first report of an angio-oedema associated with VRC.