Sulfonyl-substituted zinc phthalocyanine micelles with long-lived triplet states enable durable photodynamic immunotherapy
Nanoscale Advances, cilt.8, sa.18, ss.5102-5107, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 8 Sayı: 18
- Basım Tarihi: 2026
- Doi Numarası: 10.1039/d6na00602g
- Dergi Adı: Nanoscale Advances
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Compendex, INSPEC, Directory of Open Access Journals
- Sayfa Sayıları: ss.5102-5107
- Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Evet
Özet
Pluronic® P123 micelles stabilized a sulfonyl-substituted zinc(ii) phthalocyanine, prolonged its triplet-state lifetime, and preserved ROS photochemistry under biologically relevant conditions. Pharmacokinetic-guided C-PDT at a 24 h DLI remained insufficient as monotherapy, whereas combination with PD-L1 blockade produced durable tumor control. Rechallenge experiments after PDT additionally revealed complete long-term antitumor immune memory.