Sulfonyl-substituted zinc phthalocyanine micelles with long-lived triplet states enable durable photodynamic immunotherapy
Nanoscale Advances, vol.8, no.18, pp.5102-5107, 2026 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 8 Issue: 18
- Publication Date: 2026
- Doi Number: 10.1039/d6na00602g
- Journal Name: Nanoscale Advances
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Compendex, INSPEC, Directory of Open Access Journals
- Page Numbers: pp.5102-5107
- Acibadem Mehmet Ali Aydinlar University Affiliated: Yes
Abstract
Pluronic® P123 micelles stabilized a sulfonyl-substituted zinc(ii) phthalocyanine, prolonged its triplet-state lifetime, and preserved ROS photochemistry under biologically relevant conditions. Pharmacokinetic-guided C-PDT at a 24 h DLI remained insufficient as monotherapy, whereas combination with PD-L1 blockade produced durable tumor control. Rechallenge experiments after PDT additionally revealed complete long-term antitumor immune memory.