Effects of citicoline administration on synaptic proteins in rapid movement rats

ÇAKIR A., ÖCALAN B., KOÇ C., SÜYEN G., CANSEV M., KAHVECİ N.

IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, cilt.25, sa.5, ss.562-568, 2022 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 25 Sayı: 5
  • Basım Tarihi: 2022
  • Doi Numarası: 10.22038/ijbms.2022.60756.13462
  • Dergi Adı: IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, EMBASE, Index Islamicus, Veterinary Science Database, Directory of Open Access Journals
  • Sayfa Sayıları: ss.562-568
  • Anahtar Kelimeler: Citicoline, Postsynaptic density, protein-95, REM sleep, Sleep deprivation, Synapsin, Synapsin I, Synaptophysin, PLUS DOCOSAHEXAENOIC ACID, SLEEP-DEPRIVATION, CDP-CHOLINE, FUNCTIONAL RECOVERY, NERVE REGENERATION, GENE-EXPRESSION, MEMORY, INVOLVEMENT, METABOLITES, PLASTICITY
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Evet

Özet

Objective(s): Sleep has a pivotal role in learning-memory and sleep deprivation (SD) negatively affects synaptic functioning. Cytidine-5-diphosphocholine (Citicoline) has been known to improve learning and memory functions. Our objective was to explore the effects of Citicoline on hippocampal and cortical synaptic proteins in rapid eye movement (REM) sleep-deprived rats.