Electrophysiological and Histopathological Evaluation of Effects of Sodium-2 Mercaptoethanesulfonate Used for Middle Ear Surgery on Facial Nerve Functions

Egilmez O. K., Kokten N., BARAN M., KALCIOĞLU M. T., Ekici I. D., Tekin M.

JOURNAL OF INTERNATIONAL ADVANCED OTOLOGY, vol.14, no.2, pp.239-244, 2018 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 14 Issue: 2
  • Publication Date: 2018
  • Doi Number: 10.5152/iao.2017.3888
  • Journal Name: JOURNAL OF INTERNATIONAL ADVANCED OTOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.239-244
  • Keywords: MESNA, rat, electromyography, histopathology, CHOLESTEATOMA, MESNA
  • Acibadem Mehmet Ali Aydinlar University Affiliated: No

Abstract

OBJECTIVE: Sodium-2-mercaptoethanesulfonate (MESNA) is widely used in medicine because of its antioxidant and mucolytic effects. In recent years, it has been used in otologic surgery. Because it cleaves disulfide bonds, it is used to easily dissect the epithelial matrix in cholesteatoma and atelectasis. In this study, we hypothesized that MESNA does not have any toxic effect on the facial nerve, and the effects of MESNA on the facial nerve were examined histologically and electrophysiologically.