Cutaneous rhabdomyosarcoma with FUS::TFCP2 fusion: A case report emphasizing early detection
JOURNAL OF CUTANEOUS PATHOLOGY, cilt.50, sa.12, ss.1059-1064, 2023 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 50 Sayı: 12
- Basım Tarihi: 2023
- Doi Numarası: 10.1111/cup.14526
- Dergi Adı: JOURNAL OF CUTANEOUS PATHOLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, Veterinary Science Database
- Sayfa Sayıları: ss.1059-1064
- Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Evet
Özet
Rhabdomyosarcoma with TFCP2 rearrangement is a recently identified malignant neoplasm characterized by immunohistochemical evidence of rhabdomyoblastic differentiation, keratin expression, upregulation of ALK, and an aggressive clinical course. This neoplasm has a tendency to affect craniofacial bones, with only a few reported cases of extra-osseous tumors. Here, we present a case of cutaneous rhabdomyosarcoma with FUS::TFCP2 fusion in a 35-year-old female. Notably, the tumor exhibited a pathologic spectrum, initially resembling sclerosing dermatitis at presentation but progressing into a high-grade malignant tumor within 8 months. The distinctive immunoprofile of this neoplasm highlights the importance of early molecular studies for diagnosis, even in the presence of low-grade cytomorphology. Early detection may offer an opportunity for timely resection before the tumor becomes unresectable.