Medeniyet Medical Journal, cilt.33, sa.2, ss.112-118, 2018 (Hakemli Dergi)
In this study, it was aimed to investigate the bio pathogenesis of
the cases diagnosed with meningioma in the light of the literatu- re. The patients (n=79) operated
due to the meningioma in neu- rosurgery department between 2005 and 2010 were retrospec- tively
examined. Findings that may affect the biological behavior and prognosis of the tumours
recorded in these reported data were evaluated. A total of 79 cases meeting the research
criteria were included in the study. When the histopathological grade of the cases was examined, it
was seen that 59 cases (74.7%) were grade I and 20 cases (25.3%) were grade II. When the relation
between the localization and histological grade of the cases was examined, it was determined that
the meningiomas were most frequently located in convexity and that most of grade II cases were
localized at this site. Preoperative peritumoral oedema was found to be more prevalent, especially
in the sphenoid wing and convexity meningiomas. A total of 9 cases of recurrence (11.4%) occurred
during follow-up period. When carrying out evaluati- on between surgical resection grade and
recurrent cases, it was detected that all cases where it was performed Simpson grade IV and
Kobayashi grade IVA and IVB resection had a recurrence. When the localization of recurrent cases
was examined, it was seen that 4 cases (%44.4) were sphenoid wing meningioma, 2 cases
(%22.2) were parasagittal meningioma, 1 case (%11.1) was tuberculosis sellae meningioma and 1
case (%11.1) was int- raventricular meningioma. In our study, histopathologic subtype and surgical
resection grade were found to play a significant role in prognosis in meningiomas. It was
also thought that the presence of peritumoral oedema and tumour localization could affect the
biological behavior and prognosis of the meningioma. Findings obtained should be supported by
multi-center studies that will include the cases of different races with more series.