Quercetin Improves Inflammation, Oxidative Stress, and Impaired Wound Healing in Atopic Dermatitis Model of Human Keratinocytes

Beken B., SERTTAŞ R., Yazicioglu M., Turkekul K., ERDOGAN S.

PEDIATRIC ALLERGY IMMUNOLOGY AND PULMONOLOGY, cilt.33, sa.2, ss.69-79, 2020 (SCI-Expanded) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 33 Sayı: 2
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1089/ped.2019.1137
  • Dergi Adı: PEDIATRIC ALLERGY IMMUNOLOGY AND PULMONOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Agricultural & Environmental Science Database, BIOSIS, CAB Abstracts, CINAHL, EMBASE, Veterinary Science Database
  • Sayfa Sayıları: ss.69-79
  • Anahtar Kelimeler: atopic dermatitis, inflammation, quercetin, keratinocyte, wound healing, THYMIC STROMAL LYMPHOPOIETIN, STEM-CELL SURVIVAL, EPITHELIAL-CELLS, TNF-ALPHA, IN-VITRO, SKIN, MIGRATION, EXPRESSION, CYTOKINES, ACTIVATION
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

Background: Atopic dermatitis (AD) is a common inflammatory skin disease with complex pathogenesis. Natural flavonoids exhibit strong anti-inflammatory and antioxidant properties in many human diseases. In this study, the potential bioactive effect of quercetin, a polyphenolic plant-derived flavonoid, on the AD model of human keratinocytes was evaluated.